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M9630348.TXT
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1996-02-27
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Document 0348
DOCN M9630348
TI Not only Th2 cells but also Th1 and Th0 cells express CD30 after
activation.
DT 9603
AU Bengtsson A; Johansson C; Linder MT; Hallden G; van der Ploeg I;
Scheynius A; Department of Laboratory Medicine, Karolinska Hospital,;
Stockholm, Sweden.
SO J Leukoc Biol. 1995 Dec;58(6):683-9. Unique Identifier : AIDSLINE
MED/96107361
AB To investigate whether the CD30 molecule, expressed only by a minority
of T and B cells, defines a subtype of T helper cells, Pityrosporum
orbiculare-specific CD4+ T cell clones were assessed for CD30 protein
and gene expression. The clones were defined as Th1, Th0, and Th2
according to their cytokine mRNA profile detected by reverse
transcription PCR (RT-PCR). The kinetics of CD30 expression after OKT3
(anti-CD3) stimulation was analyzed by flow cytometry,
immunocytochemistry, and RT-PCR. OKT3 activation induced a high
expression of CD30 in cells of both Th1 and Th0 as well as Th2 type
after 1-3 days. A difference between the clones was noted in that the
Th2 clones remained highly positive in CD30 expression, whereas
expression in the other clones started to decline from day 3. These data
indicate that CD30 is expressed in activated CD4+ T cells of all three
subtypes, and that the expression is sustained in Th2 cells.
DE Antigens, CD30/*ANALYSIS/GENETICS Base Sequence Clone Cells
CD4-Positive T-Lymphocytes/*IMMUNOLOGY Human Interleukin-13/GENETICS
*Lymphocyte Transformation Molecular Sequence Data RNA,
Messenger/ANALYSIS Support, Non-U.S. Gov't Th1 Cells/*IMMUNOLOGY Th2
Cells/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).